An improved model for fragment-based lead generation at AstraZeneca

•AZ fragment libraries designed for primary screening techniques, X-ray, NMR and SPR.•Planar and 3D fragments are shown to be complementary in exploring binding pockets.•49% of all fragment hits at AZ from 2012 to 2015 have been 3D in nature (PBF >0.25).•The proportion of 3D hits for PPI targets and all other target classes is the same.