TEMPO-Catalyzed Aminophosphinoylation of Ethers via Tandem C(sp3)–H and C(sp3)–O Bond Cleavage

A new TEMPO-catalyzed aminophosphinoylation of ethers with amines and H-phosphine oxides was developed for the synthesis of α-aminophosphine oxides. This metal-free aminophosphinoylation reaction could be conducted under mild conditions through tandem C­(sp3)–H and C­(sp3)–O bond cleavage. The present method offers a facile and efficient approach to broad range of α-aminophosphine oxide derivatives in moderate to good yields with excellent functional group tolerance.