Accuracy of the Epic Sepsis Prediction Model in a Regional Health System.

Interest in an electronic health record-based computational model that can accurately predict a patientu0027s risk of sepsis at a given point in time has grown rapidly in the last several years. Like other EHR vendors, the Epic Systems Corporation has developed a proprietary sepsis prediction model (ESPM). Epic developed the model using data from three health systems and penalized logistic regression. Demographic, comorbidity, vital sign, laboratory, medication, and procedural variables contribute to the model. The objective of this project was to compare the predictive performance of the ESPM with a regional health systemu0027s current Early Warning Score-based sepsis detection program.