High Sensitive Cardiac Troponin T Predicts Long-Term Risk of Incident HF Independent of Cardiovascular Risk Factors and Cardiac Structure/Function in a Multi-Ethnic Population Without CVD: The Multi-Ethnic Study of Atherosclerosis

Introduction: Although small elevations of high sensitive cardiac troponin T (hs-cTnT) have been associated with incident heart failure (HF), the robustness of this finding across a large spectrum of age in a contemporary ethnically diverse population free of cardiovascular disease (CVD) is unknown. Hypothesis: Among middle age to older adult MESA study participants with a baseline cardiac magnetic resonance (CMR) study, hs-cTnT level will identify risk of incident HF independent of demographics, risk factors and CMR structural findings. Methods: MESA includes 6814 adults aged 45-84 and free of known CVD. hs-cTnT was measured from previously frozen plasma in 99.5% using the Cobas e601 (Roche Diagnostics). 4986 also had baseline CMR exams and were included in this analysis. 3341 (67%) of participants had a hs-cTnT ≥ 3 ng/L (limit of detection [LOD]). hs-cTnT was considered as a continuous measure and as 5 categories (u003cLOD, and 4 additional categories ≥LOD). Incident HF was compared across hs-cTnT categorie...