A novel method for strict intranasal delivery of non-replicating RSV vaccines in cotton rats and non-human primates.

Michael P Citron,Manishkumar Patel,Mona Purcell,Shu-An Lin,Daniel J Rubins,Paul McQuade,Cheryl Callahan,Alexa Gleason, Ioan Petrescu,Walter Knapp, Chinedu Orekie,Sai Chamarthy,Zhiyun Wen,Sinoeun Touch,Matthew Pine,Jane Fontenot,Cameron Douglas,Xiaoping Liang,Amy S Espeseth

Vaccine（2018）

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摘要

•The importance of immunization method for each preclinical species.•Traditional immunization methods distribute incola in both URT and LRT.•Immune responses can differ depending on biodistribution.•Dosing preclinical species inaccurately can lead to exaggerated results.•Used imaging to define a method for strict intranasal immunization.

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关键词

Intranasal immunization,Animal models,Respiratory syncytial virus,Vaccine,Cotton rat and non-human primate

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