EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation

Beatrice Rondinelli,Ewa Gogola,Hatice Yücel,Alexandra A. Duarte,Marieke van de Ven,Roxanne van der Sluijs,Panagiotis A. Konstantinopoulos,Jos Jonkers,Raphaël Ceccaldi,Sven Rottenberg,Alan D. D’Andrea

NATURE CELL BIOLOGY（2017）

引用 249|浏览12

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摘要

Rondinelli et al. show that EZH2-mediated H3K27me3 at stalled replication forks recruits MUS81 nuclease to facilitate fork degradation. Loss of EZH2 contributes to PARPi resistance in BRCA2-deficient tumours.

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关键词

Cancer,DNA damage and repair,Histone post-translational modifications,Life Sciences,general,Cell Biology,Cancer Research,Developmental Biology,Stem Cells

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