Implications of the N-Terminal Heterogeneity for the Neuronal K-Cl cotransporter KCC2 Function.

Marika Markkanen,Anastasia Ludwig,Stanislav Khirug,Evgeny Pryazhnikov,Shetal Soni,Leonard Khiroug,Eric Delpire,Claudio Rivera,Matti S Airaksinen,Pavel Uvarov

Brain Research（2017）

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摘要

•KCC2a isoform is expressed at the neuronal plasma membrane.•KCC2a isoform mediates chloride extrusion in cultured neurons.•SPAK differently regulates kinetic activity of KCC2a and KCC2b isoforms.

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关键词

GABA,SPAK,HA-SPAK,OSR1,DNSPAK

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