The role of protein dynamics in the evolution of new enzyme function

Eleanor Campbell,Miriam Kaltenbach,Galen J Correy,Paul D Carr,Benjamin T Porebski,Emma K Livingstone,Livnat Afriat-Jurnou,Ashley M Buckle,Martin Weik,Florian Hollfelder,Nobuhiko Tokuriki,Colin J Jackson

NATURE CHEMICAL BIOLOGY（2016）

引用 184|浏览35

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摘要

nalysis of the structures and dynamics of intermediates and engineered mutants from directed protein evolution experiments reveals how dynamic conformational changes are harnessed across evolutionary trajectories to generate new catalytic functions.

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关键词

X-ray crystallography,Protein design,Enzymes,Proteins

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