The Role Of Telomere Protective Protein Tpp1 In Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is a worldwide malignancy. To date, surgery is still the most effective treatment with curative potential, but only about 20% of patients with HCC are eligible for surgical intervention. Therefore exploring the pathogenesis of liver cancer, looking for molecules targeting therapy, is very important. Telomeres, the chromosome extremities, are protected by specific proteins, such as POT1, RAP1, TIN2, TRF1, TRF2,and TPP1. More and more findings have discovered that TPP1 plays an important role in the tumorigenesis. However, the mechanism of TPP1 in HCC remains unknown. The purpose of this study is to explore the role of TPP1 in HCC. Currently 42 cases of HCC patients were recruited in this study. First, the patients9 tumor tissue, adjacent tissue and normal tissue were analyzed by Western blot. The results showed that TPP1 expression in patients9 adjacent tissue and normal tissue was lower than that in tumor tissue, respectively (P Citation Format: Jiang Zou, Ru Sun, Jingruo Xia, Dan Xiao, Chang Liu, Hebin Liao, Lei Xu, Qiang Ma, Yan Cai, Jingdong Li, Xiaolan Guo. The role of telomere protective protein TPP1 in hepatocellular carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 341.