"What If I Keep My Breasts?" Extended Follow-Up Of Unaffected Brca Mutation Carriers Diagnosed With Breast Cancer (Bc) In The Toronto Magnetic Resonance Imaging (Mri) Screening Study.

1523Background: The addition of MRI to mammography for screening BRCA mutation carriers detects significantly earlier stage BC but, with median follow-up of u003c 10 years in all reports to date, the long-term prognosis of these cancers is uncertain. Moreover, while the short-term risk of ipsilateral recurrence for carriers who opt for breast conservation (BCT) are reported to be similar to that of non-carriers, the risk of late new breast primaries may be substantially higher. We report the long-term ipsilateral, contralateral, and distant recurrence as well as survival results for the previously unaffected women with BC diagnosed in the Toronto MRI screening study. Methods: From 07/1997 to 06/2009, 380 BRCA mutation carriers with no history of BC or ovarian cancer completed 1 to 9 rounds of annual screening with MRI and mammography; 41 cancers (30 invasive) were detected (38 by MRI, 5 by mammography) in 40 women (20 BRCA1, 20 BRCA2), median age at diagnosis 48 (32 to 68), followed annually for recurrence an...