Molecular Imaging of Apoptosis in Cancer Therapy-Related Cardiac Dysfunction Before LVEF Reduction

Takehiro Nakahara,Artiom Petrov,Takashi Tanimoto,Farhan Chaudhry,Navneet Narula, Surya V. Seshan,Jeffrey A. Mattis,Koon Pak,Gagan Sahni,Aarti Sonia Bhardwaj,Partho P. Sengupta,Amy Tiersten,H. William Strauss,Jagat Narula

JACC: Cardiovascular Imaging（2018）

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摘要

Detecting chemotherapy-related cardiac dysfunction (CRCD) before a decrease in left ventricular ejection fraction (LVEF) or an enzyme leak may help employ strategies to preserve ventricular function. Although the mechanisms of CRCD are not fully elucidated, myocyte apoptosis has been proposed to

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