PD28-03 CORRELATION BETWEEN A GENOMICS TEST AND ADVERSE PATHOLOGY AFTER RADICAL PROSTATECTOMY AMONG ACTIVE SURVEILLANCE CANDIDATES

RESULTS: Over a median 44-months of follow-up, 206 (42%) and 227 (46%) men progressed pathologically and therapeutically.Men who progressed had worse pathological characteristics at diagnosis (PSA, prostate volume, number of positive cores, and max percent of core involvement; p<0.05).Results of the 5 most highly correlated SNPs are presented in Table 1.After correcting for multiple analyses, one SNP (rs4464333) remained associated with pathological progression (HR 5.51, 95%CI 3.01-10.1,p¼3x10 -8 ) and one SNP (rs6583016) remained borderline-associated with therapeutic progression (HR 2.30, 95%CI 1.67-3.17,p¼3x10 -7 ).Of the 11 SNPs previously studied for grade progression, rs7141529 associated with therapeutic progression (HR 1.32 95%CI 1.02-1.73,p¼0.03).CONCLUSIONS: We identified 2 novel germline genotypic variants that significantly associated with an increased risk of progression in men undergoing AS.These findings may improve patient selection for, and follow-up on AS, and need validation in other cohorts.