Adoptive Cell Therapy For Metastatic Melanoma: A Uk Centre Experience

9060 Background: Adoptive cell therapy (ACT) with tumour infiltrating lymphocytes (TIL) has consistently demonstrated impressive clinical results in several international studies in the management of metastatic melanoma. We describe our experience as the only UK cancer centre providing TIL therapy. Methods: TIL are cultured from resected tumour samples as previously described. Infusion is preceded by non-myeloablative lymphodepleting chemotherapy (high dose cyclophosphamide and fludarabine) and followed by intravenous high dose interleukin 2 (HD-IL2). Results: Eleven patients have been treated to date: eight with cutaneous melanoma, two with ocular melanoma and one patient with mucosal melanoma. All patients had metastatic disease and were heavily pre-treated with a combination of targeted agents and immunotherapies (anti-CTLA4 and anti-PD1 antibodies). In the ten patients currently evaluable, 60% achieved an objective clinical response according to the response evaluation criteria in solid tumours. Five ...