Influence Of Chemotherapy On The Sparc Expression In Gastric Cancer.

e15087 Background: The expression of tumor biomarkers may change after chemotherapy. However, whether secreted protein, acidic and rich in cysteine (SPARC) expression changes after chemotherapy in gastric cancer (GC) is unclear. We investigated the influence of chemotherapy on SPARC expression in GC. Methods: Immunohistochemistry was used to analyze SPARC expression in 132 GC cases (including 54 cases with preoperative chemotherapy and 78 cases without preoperative chemotherapy). We assessed SPARC expression of postoperative specimens with and without preoperative chemotherapy to analyze the influence of chemotherapy on SPARC expression. Results: SPARC was highly expressed in GC compared with the desmoplastic stroma surrounding tumor cells and noncancerous tissues. High SPARC expression correlated with invasion depth, lymph node, and TNM stage. After chemotherapy, a lower proportion of high SPARC expression was observed in patients with preoperative chemotherapy than in the controls. For 54 patients with ...