Sphingosine kinase 1 participates in the activation, proliferation and survival of chronic lymphocytic leukemia cells.

María Belén Almejún,Mercedes Borge,Ana Colado,Esteban Enrique Elías,Enrique Podaza,Denise Risnik,Carlos Daniel De Brasi,Carmen Stanganelli,Irma Slavutsky,María Cabrejo,Horacio Fernández-Grecco,Raimundo Fernando Bezares,Santiago Cranco,Rubén Burgos, Julio César Sánchez-Ávalos,Pablo Oppezzo,Mirta Giordano,Romina Gamberale

HAEMATOLOGICA（2017）

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摘要

Sphingosine kinases (SKs) have received the most attention as important enzymes in cancer biology. They participate in the regulation of bioactive sphingolipid metabolism by producing sphingosine-1 phosphate (S1P) which mediates several biological functions, including cell growth, differentiation,

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