Suppression of RUNX1/ETO oncogenic activity by a small molecule inhibitor of tetramerization

Julia Schanda,Chun-Wei Lee, Katharina Wohlan,Uta Müller-Kuller,Hana Kunkel,Isabell Quagliano-Lo Coco,Stefan Stein,Alexander Metz,Joachim Koch,Jörn Lausen,Uwe Platzbecker,Hind Medyouf,Holger Gohlke,Michael Heuser,Matthias Eder,Manuel Grez,Michaela Scherr,Christian Wichmann

HAEMATOLOGICA（2017）

引用 11|浏览29

暂无评分

摘要

RUNX1/ETO, the product of the t(8;21) chromosomal translocation, is required for the onset and maintenance of one of the most common forms of acute myeloid leukemia (AML). RUNX1/ETO has a modular structure and, besides the DNA-binding domain (Runt), contains four evolutionary conserved functional

查看译文

关键词

oncogenic activity,small molecule inhibitor,runx1/eto

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要