The epigenetically-regulated miR-34a targeting c-SRC suppresses RAF/MEK/ERK signaling pathway in K-562 cells

•miR-34a was down-regulated in K-562 and CML patients due to DNA hypermethylation.•miR-34a was over expressed in K-562 cells with miR-34a lentiviruses infection.•miR-34a regulated c-SRC gene by binding two sites in c-SRC 3′ UTR.•miR-34a down-regulation resulted in c-SRC up-regulation in the CML patients.•miR-34a suppressed the RAF/MEK/ERK signalling pathway by down-regulating c-SRC.