The absolute number of regulatory T cells in unmanipulated peripheral blood grafts predicts the occurrence of acute graft-versus-host disease post haplo-identical hematopoietic stem cell transplantation

Ding L,Heng Zhu,Yang Yang,Yan Hm,Hai-Hong Zhang,Dong-Mei Han, Zhi-Dong Wang,Xiao-Li Zheng,Jing Liu,Zhu L, Mei-Xue,Zi-Kuan Guo,Wang Hx

Leukemia Research（2017）

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摘要

•Tregs in PB increased significantly after G-CSF administration.•Tregs in PB exhibited a stronger inhibitory effect on T cell proliferation.•A high number of Tregs in PB is associated with reduced risk of aGVHD in haplo-HSCT.

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关键词

Regulatory T cells,Haplo-identical hematopoietic stem cell transplantation,Acute graft versus host disease

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