Role of LRRTMs in synapse development and plasticity.

Reiko T. Roppongi,Benyamin Karimi,Tabrez J. Siddiqui

Neuroscience Research（2017）

引用 36|浏览6

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摘要

•LRRTMs are an emerging family of postsynaptic synapse organizing proteins.•They are strongly associated with neuropsychiatric disorders.•They bind to presynaptic neurexins and heparan sulphate proteoglycans.•They mediate excitatory synapse development without affecting inhibitory synapses.•They are required for synaptic plasticity, particularly long-term potentiation.

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关键词

LRRTM,Synapse development,Synaptic plasticity,Synapse formation,Autism,Schizophrenia,Neurodevelopment,Neural circuit,Neurexin,Heparan sulphate proteoglycan,HSPG

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