Neuregulin-1 and schizophrenia in the genome-wide association study era

Md Shaki Mostaid,David Lloyd,Benny Liberg,Suresh Sundram,Avril Pereira,Christos Pantelis,Tim Karl,Cynthia Shannon Weickert,Ian P. Everall,Chad A. Bousman

Neuroscience & Biobehavioral Reviews（2016）

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摘要

⿢We assess NRG1⿿s relevance to schizophrenia in the GWAS era.⿢The past decade of clinical research on NRG1 and schizophrenia is summarized.⿢We review preclinical work on NRG1⿿s role in excitatory/inhibitory neurotransmission.⿢We propose a strategy forward for future NRG1 research in schizophrenia.

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关键词

Neuregulin 1,Schizophrenia,Psychosis,Excitatory neurotransmission,Inhibitory neurotransmission,Neuroimaging,Genotype,Transcript

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