Relative sensitivities of DCE-MRI pharmacokinetic parameters to arterial input function (AIF) scaling

Xin Li,Yu Cai,Brendan Moloney,Yiyi Chen,Wei Huang,Mark Woods, Fergus V. Coakley, William D. Rooney,Mark G. Garzotto,Charles S. Springer

Journal of Magnetic Resonance（2016）

引用 36|浏览28

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摘要

•In DCE-MRI pharmacokinetic modeling, arterial input function (AIF) scaling is common.•Ktrans and ve model parameters with AIF-scaling.•The contrast agent intravasation rate constant (kep) is insensitive to AIF-scaling.•The cellular water efflux rate constant (kio) is insensitive to AIF-scaling error.

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关键词

Dynamic-Contrast-Enhanced,Water exchange,Arterial input function,Contrast reagent,AIF scaling,Prostate cancer

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