Alkyl derivatives of 1,3,5-triazine as histamine H 4 receptor ligands.

Dorota Łażewska,Szczepan Mogilski,Stefanie Hagenow,Kamil Kuder,Monika Głuch-Lutwin,Agata Siwek,Małgorzata Więcek,Maria Kaleta,Ulla Seibel,Armin Buschauer,Barbara Filipek,Holger Stark,Katarzyna Kieć-Kononowicz

Bioorganic & Medicinal Chemistry（2019）

引用 9|浏览43

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摘要

•Alkyl derivatives of 1,3,5-triazine.•Good human histamine H4 receptor affinities.•Antagonism in the cellular aequorin-based functional assay.•Antagonism in [35S]GTPγS binding assay.•Antinociceptive activity in in vivo tests.

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关键词

Histamine H4 receptors,Histamine H4 ligands,1,3,5-Triazine,Docking,Pain

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