Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses Aysu Okbay , Bart M L Baselmans , Jan-Emmanuel De Neve , Patrick Turley , Michel G Nivard , Mark Alan Fontana , S Fleur W Meddens , Richard Karlsson Linnér , Cornelius A Rietveld , Jaime Derringer , Jacob Gratten , James J Lee , Jimmy Z Liu , Ronald de Vlaming , Tarunveer S Ahluwalia , Jadwiga Buchwald , Alana Cavadino , Alexis C Frazier-Wood , Nicholas A Furlotte , Victoria Garfield , Marie Henrike Geisel , Juan R Gonzalez , Saskia Haitjema , Robert Karlsson , Sander W van der Laan , Karl-Heinz Ladwig , Jari Lahti , Sven J van der Lee , Penelope A Lind , Tian Liu , Lindsay Matteson , Evelin Mihailov , Michael B Miller , Camelia C Minica , Ilja M Nolte , Dennis Mook-Kanamori , Peter J van der Most , Christopher Oldmeadow , Yong Qian , Olli Raitakari , Rajesh Rawal , Anu Realo , Rico Rueedi , Börge Schmidt , Albert V Smith , Evie Stergiakouli , Toshiko Tanaka , Kent Taylor , Gudmar Thorleifsson , Juho Wedenoja , Juergen Wellmann , Harm-Jan Westra , Sara M Willems , Wei Zhao , Najaf Amin , Andrew Bakshi , Sven Bergmann , Gyda Bjornsdottir , Patricia A Boyle , Samantha Cherney , Simon R Cox , Gail Davies , Oliver S P Davis , Jun Ding , Nese Direk , Peter Eibich , Rebecca T Emeny , Ghazaleh Fatemifar , Jessica D Faul , Luigi Ferrucci , Andreas J Forstner , Christian Gieger , Richa Gupta , Tamara B Harris , Juliette M Harris , Elizabeth G Holliday , Jouke-Jan Hottenga , Philip L De Jager , Marika A Kaakinen , Eero Kajantie , Ville Karhunen , Ivana Kolcic , Meena Kumari , Lenore J Launer , Lude Franke , Ruifang Li-Gao , David C Liewald , Marisa Koini , Anu Loukola , Pedro Marques-Vidal , Grant W Montgomery , Miriam A Mosing , Lavinia Paternoster , Alison Pattie , Katja E Petrovic , Laura Pulkki-Råback , Lydia Quaye , Katri Räikkönen , Igor Rudan , Rodney J Scott , Jennifer A Smith , Angelina R Sutin , Maciej Trzaskowski , Anna E Vinkhuyzen , Lei Yu , Delilah Zabaneh , John R Attia , David A Bennett , Klaus Berger , Lars Bertram , Dorret I Boomsma , Harold Snieder , Shun-Chiao Chang , Francesco Cucca , Ian J Deary , Cornelia M van Duijn , Johan G Eriksson , Ute Bültmann , Eco J C de Geus , Patrick J F Groenen , Vilmundur Gudnason , Torben Hansen , Catharine A Hartman , Claire M A Haworth , Caroline Hayward , Andrew C Heath , David A Hinds , Elina Hyppönen , William G Iacono , Marjo-Riitta Järvelin , Karl-Heinz Jöckel , Jaakko Kaprio , Sharon L R Kardia , Liisa Keltikangas-Järvinen , Peter Kraft , Laura D Kubzansky , Terho Lehtimäki , Patrik K E Magnusson , Nicholas G Martin , Matt McGue , Andres Metspalu , Melinda Mills , Renée de Mutsert , Albertine J Oldehinkel , Gerard Pasterkamp , Nancy L Pedersen , Robert Plomin , Ozren Polasek , Christine Power , Stephen S Rich , Frits R Rosendaal , Hester M den Ruijter , David Schlessinger , Helena Schmidt , Rauli Svento , Reinhold Schmidt , Behrooz Z Alizadeh , Thorkild I A Sørensen , Tim D Spector , John M Starr , Kari Stefansson , Andrew Steptoe , Antonio Terracciano , Unnur Thorsteinsdottir , A Roy Thurik , Nicholas J Timpson , Henning Tiemeier , André G Uitterlinden , Peter Vollenweider , Gert G Wagner , David R Weir , Jian Yang , Dalton C Conley , George Davey Smith , Albert Hofman , Magnus Johannesson , David I Laibson , Sarah E Medland , Michelle N Meyer , Joseph K Pickrell , Tõnu Esko , Robert F Krueger , Jonathan P Beauchamp , Philipp D Koellinger , Daniel J Benjamin , Meike Bartels , David Cesarini Nature Genetics（2016）
摘要
Daniel Benjamin, Meike Bartels, Philipp Koellinger and colleagues report a genome-wide association meta-analysis of subjective well-being, depressive symptoms and neuroticism. The study leverages a large sample size together with genetic correlations between the phenotypes to identify, with high confidence, loci associated with each phenotype.
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