Prospective Whole-Genome Sequencing In Tuberculosis Outbreak Investigation, France, 2017-2018

Charlotte Genestet,Caroline Tatai,Jean-Luc Berland,Jean-Baptiste Claude,Emilie Westeel,Elisabeth Hodille,Isabelle Fredenucci,Jean-Philippe Rasigade,Michael Ponsoda,Veronique Jacomo, Anne Vachee, Alice Gaudart,Jean-Louis Gaillard,Anne-Laure Roux,Florence Ader,Karim Tararbit,Garance Terpant,Juliet E. Bryant,Gerard Lina,Oana Dumitrescu

EMERGING INFECTIOUS DISEASES（2019）

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摘要

During June 2017-April 2018, active tuberculosis with Beijing SIT1 isolates was diagnosed in 14 persons living in 4 distant cities in France. Whole-genome sequencing indicated that these patients belonged to a single transmission chain. Whole-genome sequencing-based laboratory investigations enabled prompt tracing of linked cases to improve tuberculosis control.

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关键词

France,Mycobacterium tuberculosis,TB,Tuberculosis,bacteria,disease outbreaks,drug susceptibility,epidemiologic monitoring,tuberculosis and other mycobacteria,whole-genome sequencing

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