DNA damage repair alterations modulate M2 polarization of microglia to remodel the tumor microenvironment via the p53-mediated MDK expression in glioma

Xiangqi Meng,Chunbin Duan,Hengyuan Pang,Qun Chen,Bo Han,Caijun Zha,Magafurov Dinislam,Pengfei Wu,Ziwei Li,Shihong Zhao,Ruijia Wang,Lin Lin,Chuanlu Jiang,Jinquan Cai

EBioMedicine（2019）

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摘要

•Gliomas with DNA damage repair alterations had distinct genomic variation spectrum.•DDR alterations exhibit distinct immune phenotypes, cytokine processes and immune cell types in glioma.•DDR-related cytokines in GME have an unfavorable prognostic implication for GBM patients.•P53-mediated midkine expression derived from glioma cells promotes M2 polarization of microglia.

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关键词

DNA damage repair,Microglia,Glioma microenvironment,p53,Midkine

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