Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis.

Juliana Marques Senedese,Francisco Rinaldi-Neto,Ricardo Andrade Furtado,Heloiza Diniz Nicollela,Larissa Daniela Ribeiro de Souza,Arthur Barcelos Ribeiro,Lucas Souza Ferreira,Geórgia Modé Magalhães,Iracilda Zeppone Carlos,Jonas Joaquim Mangabeira da Silva,Denise Crispim Tavares,Jairo Kenupp Bastos

Biomedicine & Pharmacotherapy（2019）

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摘要

•Copaifera reticulata oleoresin showed antigenotoxic effect on colon.•Pre-neoplastic lesions of the colon were reduced by treatment with Copaiba oleoresin.•The oleoresin reduced the progression of carcinogenesis.•Major chemical constituent of the oleoresin showed anti-inflammatory activity.•The anti-inflammatory activity of oleoresin is involved in its chemopreventive effect.

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关键词

Copaifera reticulata Ducke,ent-polyalthic acid,Antigenotoxicity,Anticarcinogenesis,Anti-inflammatory activity

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