Synthesis And Characterization Of Novel Chiral Derivatizing Agents Containing -Keto-Anthracene Adducts (Kaas) By H-1-Nmr: Aromatic Influence And Chiral Alcohol Absolute Configuration Determination

New alternative chiral derivatizing agents, -keto-anthracene adducts (KAAs), were accomplished and the influence of aromatic moieties at the -carbon position for elucidation of the absolute configuration of chiral secondary alcohols via NMR was studied. The -benzoyl substituted KAAs strongly enhance the anisotropic effect which produced greater (RS) values than other conventional reagents. We propose a simplified model to describe the conformations and to assign the absolute configuration in several chiral alcohol samples.