Target regulation of PI3K/Akt/mTOR pathway by cannabidiol in treatment of experimental multiple sclerosis.

Sabrina Giacoppo,Federica Pollastro,Gianpaolo Grassi,Placido Bramanti,Emanuela Mazzon

Fitoterapia（2017）

引用 96|浏览8

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摘要

This study was aimed to investigate whether treatment with purified cannabidiol (CBD) may counteract the development of experimental multiple sclerosis (MS), by targeting the PI3K/Akt/mTOR pathway. Although the PI3K/Akt/mTOR pathway was found to be activated by cannabinoids in several immune and non-immune cells, currently, there is no data about the effects of CBD in the PI3K/Akt/mTOR activity in MS.

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关键词

Cannabidiol,Multiple sclerosis,PI3K/Akt/mTOR pathway,BDNF,Inflammation,Neuronal survival

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