TNFα stimulates NO release in EA.hy926 cells by activating the CaMKKβ-AMPK-eNOS pathway.

Dorota Dymkowska,Beata Drabarek, Anna Michalik,Natalia Nowak,Krzysztof Zabłocki

The International Journal of Biochemistry & Cell Biology（2019）

引用 6|浏览23

暂无评分

摘要

•eNOS is the only NO-generating enzyme in EA.hy926 cells.•AMPK regulates eNOS activity in endothelial cells stimulated with TNFα.•CaMKKβ is involved in TNFα-dependent eNOS activation.•A crosstalk between AMPK and Sirt1 plays a role in NO synthesis activated by TNFα.

查看译文

关键词

ACC,AMPK,[Ca2+]c,CaMKII,CaMKKβ,eNOS,LKB1,Sirt1,TNFα

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要