Loss of DNA methylation is related to increased expression of miR-21 and miR-146b in papillary thyroid carcinoma.

Isabella Maria Dias Payão Ortiz,Mateus Camargo Barros-Filho,Mariana Bisarro Dos Reis,Caroline Moraes Beltrami,Fabio Albuquerque Marchi,Hellen Kuasne,Luísa Matos do Canto,Julia Bette Homem de Mello,Cecilie Abildgaard,Clóvis Antônio Lopes Pinto,Luiz Paulo Kowalski,Silvia Regina Rogatto

Clinical epigenetics（2018）

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摘要

The increased expression of miR-21 and miR-146b due to loss of DNA methylation in PTC resulted in the disruption of the transcription machinery and biological pathways. These miRNAs are potential diagnostic biomarkers, and these findings provide support for future development of targeted therapies.

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关键词

Carcinoma,DNA methylation,Papillary thyroid,miR-146b,miR-21,microRNA

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