Is hyperhomocysteinemia associated with the structural changes of the substantia nigra in Parkinson's disease? A two-year follow-up study.

Guohua Zhang,Chengguo Zhang,Yukai Wang,Lijuan Wang,Yuhu Zhang,Haiqun Xie,Jiancong Lu,Kun Nie

Parkinsonism & Related Disorders（2019）

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摘要

•Motor symptoms became severe with increased mean kurtosis values of the SN in PD.•This phenomenon is more prominent in PD patients with Hyperhomocysteinemia (HHCY).•HHCY is associated with the structural changes of the SN in PD patients.

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关键词

Hyperhomocysteinemia,Parkinson's disease,Substantia nigra,Motor symptoms,Diffusion kurtosis imaging

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