H NMR-based dynamic metabolomics delineates the therapeutic effects of Baoyuan decoction on isoproterenol-induced cardiac hypertrophy.

Zhiyong Du,Ran Wen,Qian Liu,Jinlong Wang,Yingyuan Lu,Mingbo Zhao,Xiaoyu Guo,Pengfei Tu,Yong Jiang

Journal of pharmaceutical and biomedical analysis（2019）

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摘要

•BYD exerted significant anti-CH roles evidenced by multi-pharmacodynamics.•BYD demonstrated a time-dependent metabolomic modulation on CH.•BYD dynamically restored CH-induced disturbances of multiple biological pathways.•Energy synthesis and antioxidant assays strengthened the metabolomic findings.

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关键词

Cardiac hypertrophy,Heart failure,Dynamic metabolomics,1H NMR,Baoyuan decoction

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