Vitamin E-based redox-sensitive salinomycin prodrug-nanosystem with paclitaxel loaded for cancer targeted and combined chemotherapy.

•The TS prodrug conjugates were designed by covalently coupling the lipophilic TOS moiety to SAL via disulfide linkages.•The TS prodrug conjugates were readily self-aggregated into stable nanoparticles.•The TS prodrug nanoparticles were tumor-targeting and glutathione-sensitive.•The TS prodrug nanoparticles were designed for synergistic salinomycin-paclitaxel combination chemotherapy.