Neutrophils: Interplay between host defense, cellular metabolism and intracellular infection.

•Neutrophil immune defence mechanism correlation with cellular metabolism.•Role of homeostatic cellular autophagy process in regulation of cytosolic and mitochondrial metabolic pathways.•Intracellular pathogens trigger/bypass host cell autophagic pathways modulating host cell immune function.•Possible metabolic targets for designing specific therapeutic regimen. against various intracellular pathogens.