Differential engagement of cognitive control regions and subgenual cingulate based upon presence or absence of comorbid anxiety with depression.

•Cognitive control deficits may cause impaired emotion regulation in mood disorders.•rMDD group showed less cognitive control network (CCN) activity during commissions.•Comorbid rMDD and anxiety showed increased salience and emotion network activity.•increased salience and emotion network activity may be compensatory in anxiety.•Comorbid anxiety is a meaningful subtype of MDD.