Highly cytotoxic natural killer cells are associated with poor prognosis in patients with cutaneous T-cell lymphoma.

Bethany Mundy-Bosse,Nathan Denlinger,Eric McLaughlin,Nitin Chakravarti, Susan Hwang,Li Chen,Hsiaoyin Charlene Mao,David Kline,Youssef Youssef,Rebecca Kohnken,Dean Anthony Lee,Gerard Lozanski,Aharon G Freud,Pierluigi Porcu,Basem William,Michael A Caligiuri,Anjali Mishra

Blood advances（2018）

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摘要

Key Points Paradoxically higher NK-cell activity in CTCL patients is associated with increased expression of phosphorylated STAT5. These highly effective NK cells are associated with poor prognosis in patients with leukemic CTCL.

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