ALA-PDT suppressing the cell growth by Akt-/Erk-mTOR-p70 s6k pathway in human SZ95 sebocytes in vitro.

Wenjie Liu,Qianqian Wang,Jiang Tuo,Yufeng Chang,Jiayi Ying,Min Jiang,Christos C Zouboulis,Leihong Xiang

Photodiagnosis and Photodynamic Therapy（2018）

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摘要

•IGF-1 had counter effects of ALA-PDT on SZ95 cells.•Rapamycin enhanced the effects of ALA-PDT on SZ95 cells.•ALA-PDT suppressed the cell growth in SZ95 cells through Akt-/Erk- mTOR pathway.•PRAS40-/RagC- mTOR pathway shows no effect in ALA-PDT suppressing SZ95 cell growth.

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关键词

ALA,PDT,mTOR,p70,4E-BP1,IGF,AMPK,Erk,PRAS40,RAG

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