Targeting the extradomain A of fibronectin allows identification of vascular resistance to antiangiogenic therapy in experimental glioma.

Güliz Acker,Sophie Käthe Piper,Anna Lena Datwyler,Thomas Broggini,Irina Kremenetskaia,Melina Nieminen-Kelhä,Janet Lips,Ulrike Harms,Susanne Mueller, Gilla Lättig-Tünnemann,Eveline Trachsel,Alessandro Palumbo,Dario Neri,Jan Klohs,Matthias Endres,Peter Vajkoczy,Christoph Harms,Marcus Czabanka

Oncotarget（2018）

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摘要

F8-SIP is highly tumor specific with time and hemodynamic dependent biodistribution. The higher vascular accumulation to remaining vessels enables molecular imaging and targeting of therapy resistant tumor vessels.

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关键词

F8,NIRF imaging,SF126,antiangiogenic resistance,glioma

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