The application of kinomic array analysis to screen for altered kinases in atrial fibrillation remodeling.

Roelien A M Meijering,Marit Wiersma,Deli Zhang,Eva A H Lanters,Femke Hoogstra-Berends,Jetse Scholma,Sander Diks,XiaoYan Qi,Natasja M S de Groot,Stanley Nattel,Robert H Henning,Bianca J J M Brundel

Heart Rhythm（2018）

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摘要

Contrasting kinomic array analyses of control and treated subject offers a versatile tool to identify kinases altered in atrial remodeling due to tachypacing, which include Akt, CDK4 and SRC. Ultimately, pharmacological targeting of altered kinases may offer novel therapeutic possibilities to treat clinical AF.

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关键词

Akt,Atrial fibrillation,Cardiomyocytes,CDK,Kinases,Kinome array,SRC

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