Translational strategy: humanized mini-organs.

•Translational research helps to develop humanized micro-physiological systems.•Decellularized and recellularized organs have preserved vascular matrix network.•The mini-organs can be a platform for disease modeling for precision medicine.•Humanized organs can be co-cultured to model systemic drug uptake.•Humanized mini-organs can provide human-relevant evidence of target engagement.