Mesenchymal stromal cells induce a permissive state in the bone marrow that enhances G-CSF-induced hematopoietic stem cell mobilization in mice.

•Administration of MSC induces macrophage depletion and downregulation of niche factors•Co-administration of MSC and G-CSF induces a two-fold increase in HSPC mobilization•Administration of MSC-derived extracellular vesicles recapitulate the effects of MSC