Epithelial barrier dysfunction in desmoglein-1 deficiency.
The Journal of allergy and clinical immunology（2018）
摘要
Desmoglein-1 deficiency is a missing link between impaired epithelial barrier function and immunological dysregulation. Our characterization of SAMEC syndrome highlighted the pivotal role of the desmoglein-1/ERBIN interaction as an inhibitor of skin inflammation via the NF-κB signaling pathway.
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