Comprehensive characteristics of the anticoagulant activity of dabigatran in relation to its plasma concentration.

Willemijn J Comuth,Linda Ø Henriksen,Daan van de Kerkhof,Steen E Husted,Steen D Kristensen,Moniek P M de Maat,Anna-Marie B Münster

Thrombosis Research（2018）

引用 19|浏览11

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摘要

•ROTEM® clotting times correlated well with dabigatran plasma concentrations.•Ecarin chromogenic assay and diluted thrombin time correlated with concentrations.•Coagulability similar in dabigatran-spiked samples and those from treated patients.•Storage for one year at −80 °C changed neither dabigatran levels nor coagulability.

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APTT,APTT-Cepha,APTT-PSL,ANOVA,CAT,CT,DMSO,DTI,ECA,ETP,EXTEM,HCl,INTEM,FIBTEM,LC-MS/MS,LD-dTT,MCF,MRM,NOAC,PT,PT-INN,PT-Owren,ROTEM,SE,SEE,TF,TQD,UPLC,VKA

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