Sparse Large-Scale Nonlinear Dynamical Modeling of Human Hippocampus for Memory Prostheses.

Dong Song,Brian S Robinson,Robert E Hampson,Vasilis Z Marmarelis,Sam A Deadwyler,Theodore W Berger

IEEE Transactions on Neural Systems and Rehabilitation Engineering（2018）

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摘要

In order to build hippocampal prostheses for restoring memory functions, we build sparse multi-input, multi-output (MIMO) nonlinear dynamical models of the human hippocampus. Spike trains are recorded from hippocampal CA3 and CA1 regions of epileptic patients performing a variety of memory-dependent delayed match-to-sample (DMS) tasks. Using CA3 and CA1 spike trains as inputs and outputs respectiv...

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关键词

Hippocampus,MIMO,Prosthetics,Rodents,Buildings,Computational modeling,Predictive models

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