Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons

NATURE MEDICINE（2018）

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摘要

Human ALS/FTD patient iPSC-derived neurons are used to uncover mechanisms by which C9ORF72 mutations cause neurodegeneration.

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关键词

Amyotrophic lateral sclerosis,Reprogramming,Biomedicine,general,Cancer Research,Metabolic Diseases,Infectious Diseases,Molecular Medicine,Neurosciences

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