Hindbrain estrogen receptor-beta antagonism normalizes reproductive and counter-regulatory hormone secretion in hypoglycemic steroid-primed ovariectomized female rats.
Neuroscience（2016）
摘要
•Hypoglycemia elevates estrogen receptor-beta (ERβ) protein in A2 metabolo-sensory neurons.•Hindbrain ERβ antagonism normalizes LH release but not preoptic GnRH-I protein content.•The ERβ antagonist PHTPP attenuates counter-regulatory hormone output during hypoglycemia.•PHTPP prevents hypoglycemic augmentation of NE in the ARH, but not other forebrain loci.•PHTPP normalizes ARH, but not AVPV preprokisspeptin protein profiles in hypoglycemic rats.
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关键词
β-END,AICAR,AMPK,ARH,CV,CV4,DMSO,ERα,ERβ,GnRH,LH,MPN,MSH,NE,NPY,OVX,pAMPK,PEN,PHTPP,POMC,PVDF,rPO,TH
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