Electrochemical [C-11]Co2 To [C-11]Co Conversion For Pet Imaging

The development of a novel electrochemicalmethodology to generate carbon-11 carbon monoxide ([C-11] CO) from cyclotron-produced carbon-11 carbon dioxide ([C-11] CO2) using Ni(cyclam) and Zn(cyclen) complexes is described. This methodology allows up to 10% yields of [C-11] CO from [C-11] CO2. Produced [C-11] CO was subsequently converted to [C-11]N-benzylbenzamide under mild conditions with a radiochemical purity (RCP) of >98%.