Plectin Controls Biliary Tree Architecture and Stability in Cholestasis.

Marketa Jirouskova, Katerina Nepomucka,Gizem Oyman-Eyrilmez,Alzbeta Kalendova,Helena Havelkova,Lenka Sarnova,Karel Chalupsky,Bjoern Schuster,Oldrich Benada,Petra Miksatkova,Martin Kuchar,Ondrej Fabian,Radislav Sedlacek,Gerhard Wiche,Martin Gregor

Journal of Hepatology（2018）

引用 24|浏览21

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摘要

•A novel liver-specific plectin knockout mouse model was generated.•Plectin deficiency leads to aberrant organization and instability of epithelial keratin filaments.•Plectin is responsible for a proper canalicular network formation and biliary tree architecture.•Plectin preserves bile duct integrity under cholestatic stress.

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关键词

Cytolinker,Keratin filaments,Bile duct ligation,DDC diet,Cell-cell junctions

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