Vulnerability of white matter tracts and cognition to the SOD2 polymorphism: A preliminary study of antioxidant defense genes in brain aging

Lauren E. Salminen,Peter R. Schofield,Kerrie D. Pierce,Steven E. Bruce,Michael G. Griffin,David F. Tate,Ryan P. Cabeen,David H. Laidlaw,Thomas E. Conturo,Jacob D. Bolzenius,Robert H. Paul

Behavioural Brain Research（2017）

引用 15|浏览25

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摘要

•The SOD2/rs4880 SNP is associated with white matter abnormalities in older adults.•The anterior thalamic radiation is vulnerable to aging in CC genotypes of SOD2.•Cingulum damage may lead to slower processing speed in SOD2 CC genotypes.•The CAT/rs1001179 SNP is not associated with brain aging in this cohort.

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关键词

Brain aging,Oxidative stress,SOD2,Catalase,White matter,Cognition

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