Dopamine dependent setting of a circadian oscillator underlying the memory for time of day
Neurobiology of Learning and Memory(2017)
摘要
•Place preferences were conditioned in mice using either amphetamine or haloperidol.•Preference for both drugs was highest at the time of day of conditioning.•A single dose of amphetamine given in the home cage on the day following place avoidance conditioning, reset the timing of the place avoidance to the amphetamine injection time, with no loss of memory for context.•Chronic haloperidol did not block the formation of a context memory but eliminated rhythmicity in the expression of place avoidance.•Results suggest that the timing of an important event is encoded by a condition entrainable oscillator that is set by an acute change in dopamine transmission at the time of the event.
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关键词
CEO,CPA,CPP,FAA,FEO,SCN,TPL,ZT
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